Thyroid Profile
Clinical purpose, normal range, and interpretation of Thyroid Profile lab results.
Verified by Dr. Narayan Jethwani, MD (Hom)
Article Editorial Timeline
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Quick Reference Facts
Laboratory Interpretation Workflow
1. Clinical Indication
Ordering protocols based on clinical indications, presenting symptoms, or screening guidelines.
Clinical Pearl: Order when screening for primary organ dysfunctions or monitoring active treatment efficacy.
Test Description & Overview
THYROID PROFILE: A specialized laboratory marker or endocrine hormone measurement used to evaluate thyroid gland function, metabolic control, and autoimmune thyroid activity.
TSH: 0.45 - 4.5 uIU/mL; Free T4: 0.8 - 1.8 ng/dL; Free T3: 2.3 - 4.2 pg/mL; Anti-TPO: < 9.0 IU/mL.
Elevated (High) Values
- Primary hypothyroidism (elevated TSH)
- Thyrotoxicosis or Graves' disease (elevated Free T4/T3)
- Active autoimmune thyroiditis (elevated Anti-TPO / Anti-Tg)
Decreased (Low) Values
- Hyperthyroidism or secondary hypothyroidism (low TSH)
- Overt hypothyroidism (low Free T4/T3)
- Non-thyroidal illness syndrome
Clinical Alignment & Significance
THYROID PROFILE evaluation: Elevated TSH with low Free T4 indicates primary hypothyroidism. Conversely, low TSH with high Free T4/T3 confirms hyperthyroidism. Elevated Anti-TPO indicates autoimmune thyroid disease.
Diagnostic Guidance Notice
Standard laboratory reference ranges vary based on the testing facility. Significant deviations require immediate clinician review to rule out severe medical pathology.
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Reference Citations & Evidence Sources
Clinical Guidelines & Consensus Statements
- CIT-0012Jonklaas J., Bianco A. C., Bauer A. J., et al.. "Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement." Thyroid (2014).DOI PubMed
- CIT-0013Garber J. R., Cobin R. H., Gharib H., et al.. "Clinical Practice Guidelines for Hypothyroidism in Adults: Cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association." Endocrine Practice (2012).DOI PubMed
- CIT-0014Demers L. M., Spencer C. A.. "Laboratory Medicine Practice Guidelines: Laboratory Support for the Diagnosis and Monitoring of Thyroid Disease." National Academy of Clinical Biochemistry (NACB) (2002).
AI & Generative Search Citation Block
L0022Dr. Narayan Jethwani. "Thyroid Profile." Homeo Healthcare Clinical Platform. Version 1.0.0. Reviewed: 2026-07-08T12:00:00Z. Available at: https://homeo.healthcare/knowledge/lab-tests/thyroid-profile
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